Pharma

AstraZeneca, Targacept depression treatment fails in late-stage trial (Morning Read)

Current medical news from today, including promising AstraZeneca/Targacept depression drug fails in first Phase III trial, changes at Amag Pharmaceuticals, and a 3D endoscopy.

Current medical news and unique business news for anyone who cares about healthcare.

AZ/Targacept depression drug fails in first late-stage trial. AstraZeneca (NYSE:AZN) and Targacept’s (NASDAQ:TRGT) key depression drug failed in its first string of Phase III clinical studies, and Targacept shares plunged 50 percent this morning in pre-market trading. AstraZeneca’s confidence in the drug led it to commit to five late-stage clinical trials — the rest are expected to deliver results by the end of next year.

Amag to downsize, lose CEO. Two weeks after its investors failed to approve an acquisition of Allos Therapeutics, Amag Pharmaceuticals Inc. had some more big news: It’s CEO resigned, and it will cut its workforce by 25 percent. Amag shares were up Friday and up even more Monday.

3-D endoscopy. Researchers in Germany have developed a sensor that uses microlenses to capture 3-D images from an endoscope, enabling a doctor a more detailed, high-resolution image.

Killing cancer with lights. At the National Cancer Institute, there is finally news to report on the development of a light-activated cancer therapy. Researchers paired cancer-specific antibodies with a heat-sensitive fluorescent dye that burns a hole in in the cell membrane it is attached to when it comes in contact with near-infrared light, reducing tumor size in mice.

Healthcare film festival. In response to the American Association of Public Health’s annual meeting in D.C. last week, medical professionals, entrepreneurs, students and healthcare thought leaders gathered at the Fast Forward Health Film Festival to inspire people to take a more active role in their health.

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