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Gene-based test for women would detect endometriosis without surgery

11:51 am by | 3 Comments

For years research has shown a delay in diagnosis and treatment of endometriosis, a condition that can cause pelvic pain and infertility in women. The lack of an inexpensive, noninvasive method for definitely identifying endometriosis has driven some recent innovation in diagnostic tools including one company that’s armed with a prototype for a DNA-based test and looking for funding.

Juneau Biosciences LLC is looking to raise $10 million, according to a new U.S. Securities and Exchange Commission filing. A call to the company was not returned, but it appears that it is testing a prototype of a DNA-based test that would determine whether a woman is predisposed to develop endometriosis.

In January, the company posted on its Facebook page that the first endometriosis prototype genetic test was going to be released to a select group of physicians’ offices for clinical trials in February. It developed the test from an analysis of DNA samples from more than 3,000 women participating in its End to Endo study, in which researchers discovered a number of DNA variations that appeared in women with endometriosis.

About 5 million U.S. women have endometriosis, which can be treated with hormone therapy or surgery. Currently, the condition can be diagnosed definitively only through a visual examination or biopsy taken via laparoscopy.  But DNA-based tests have recently drawn interest from researchers in Australia and at Yale.

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Salt Lake City-based Juneau is also working on a presymptomatic gene test to identify women at risk for preterm labor.

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Deanna Pogorelc

By Deanna Pogorelc MedCity News

Deanna Pogorelc is a Cleveland-based reporter who writes obsessively about life science startups across the country, looking to technology transfer offices, startup incubators and investment funds to see what’s next in healthcare. She has a bachelor’s degree in journalism from Ball State University and previously covered business and education for a northeast Indiana newspaper.
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3 comments
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MelissaWoodingBrasil
MelissaWoodingBrasil

Forgive me for the harsh words, but please, do not say that Endometriosis can be treated by operations or any kind of hormone replacement therapy. This is false and too many woman believe this and end up starting HRT as a "cure all" to this disease. It makes the disease progress. I have had this since I was a teenager and it runs rampant in my family. Having three operations and seeing specialists in Boston know that HRT makes more Endometriosis grow. Please research your facts before you put this out here for some person that may see this and make a choice that in the end will make more lesions and Endo cysyts appear. It is like giving Miracle Gro to a plant.

I have been part of the JB research since 2009 and have submitted repeated viles of DNA towards this research. We want to educate woman, not send them down a path of destruction.

deborahbgkelly
deborahbgkelly

The study was called End to Endo. Otherwise, thank you for sharing the company's progress on this.

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